NAD⁺ occurs naturally throughout the body, but levels decline with age – making NAD⁺ metabolism an important area of healthy ageing research.

METHODOLOGY

This studied comprised of 18 healthy adults aged 35-65 took Thrive⁺ daily, with NAD⁺, CoQ10 and a range of cardiovascular, physical, blood and mental wellbeing measures assessed at baseline and after 30 days.

The independent study was open-label and single-arm, with no placebo group; each participant was compared with their own baseline.


THE RESULTS

1. NAD⁺ increased by 49%
After 30 days, whole-blood NAD⁺ increased from 14.04 to 20.92 µg/mL – a statistically significant rise in a key molecule involved in cellular energy production.

2. CoQ10 increased by 57%
After 30 days, plasma CoQ10 increased from 5.14 to 8.06 ng/mL – also a statistically significant rise in a key compound involved in mitochondrial energy production.

3. Thrive⁺ wasn’t just increasing NAD⁺ – the body was using it
Researchers also measured 1-Methyl Nicotinamide (MNA), produced when NAD⁺ is metabolised.

MNA increased by 120% over the 30 days which suggests NAD⁺ pathways were actively being used by the body.

4. Significant improvements in mental wellbeing
Two validated clinical questionnaires showed statistically significant improvements in how participants felt.

The GHQ-12, a recognised measure of psychological wellbeing, improved by 10%, including:

• +31% confidence
  
• +23% improvement in low mood
  
• +19% concentration
  

The Profile of Mood States (POMS) also improved significantly, including:

• 32% less confusion
  
• 17% greater vigour

5. Systolic blood pressure fell by 7.7 mmHg
After 30 days, average systolic blood pressure decreased from 128.9 to 121.2 mmHg.

Systolic blood pressure measures the pressure in your arteries when your heart beats, making it an important marker of cardiovascular health.

Your cells begin producing more NAD⁺ from NR, supporting the cellular processes involved in energy production.

After 30 days of Thrive⁺, whole-blood NAD⁺ increased by 49% and CoQ10 by 57% in our pilot study.

Clinical research around this point suggests higher NAD⁺ availability may support changes in body composition, including lean muscle.

Sustained increases in NAD⁺ may support everyday energy and endurance. In one 2020 study, participants improved their 6-minute walking distance by 17.6 metres.

With continued use, the aim is to consistently support your NAD⁺ pathway and the cellular processes associated with long-term healthy ageing.

If you take blood thinners or antiplatelet medication such as warfarin, clopidogrel or aspirin, speak to your doctor or pharmacist before using Thrive⁺, as trans-resveratrol and CoQ10 may affect bleeding or warfarin activity.

Caution is also sensible if you take blood-pressure medication, and high dose zinc supplements can reduce copper absorption.

If you’re pregnant, breastfeeding, taking prescription medication or have a medical condition, check with a healthcare professional before use.