Science deep dive Vitals

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Thrive is a UK-first longevity supplement combining 4 high-impact nutrients. Together they’re backed by 1,000+ studies, and the formula was third-party tested in a human clinical trial.

Formulation

NAD⁺ is a molecule found naturally in every cell, helping turn nutrients into cellular energy. Levels naturally decline with age.

Clinically measured:
  • Whole-blood NAD⁺ increased by 49% after 30 days of Thrive⁺

Found naturally in your mitochondria, where it helps produce ATP – the usable energy your cells need to function.

Clinically measured:
  • Plasma CoQ10 increased by 57% after 30 days of Thrive⁺

A polyphenol that helps support the cellular systems involved in healthy ageing – helping cells better handle everyday wear and tear.

Studied for its role in:
  • Complementing healthy ageing
  • Supporting long-term cellular resilience
  • Maintaining cellular energy pathways

An essential mineral that supports energy production and helps keep the body’s cellular systems working as they should.

Contributes to:
  • Normal energy-yielding metabolism
  • Cell protection from oxidative stress
  • Normal connective tissue health
See full ingredients list

Science of cellular energy

Inside your cells, mitochondria turn nutrients into ATP – the usable energy your body relies on. NAD⁺ and CoQ10 both play key roles in this process.

Why NAD⁺ matters with age

NAD⁺ occurs naturally throughout the body, but levels decline with age – making NAD⁺ metabolism an important area of healthy ageing research.

Our clinical trial

Cellular energy & wellbeing pilot study

METHODOLOGY

This study comprised of 18 healthy adults aged 35-65 who took Thrive⁺ daily. NAD⁺, CoQ10 and a range of cardiovascular, physical, blood and mental wellbeing measures were assessed at baseline and again after 30 days.

The independent study was open-label and single-arm, with no placebo group; each participant was compared with their own baseline.


THE RESULTS

1. NAD⁺ increased by 49%

After 30 days, whole-blood NAD⁺ increased from 14.04 to 20.92 µg/mL – a statistically significant rise in a key molecule involved in cellular energy production.

2. CoQ10 increased by 57%
After 30 days, plasma CoQ10 increased from 5.14 to 8.06 µg/mL – also a statistically significant rise in a key compound involved in mitochondrial energy production.

3. Thrive⁺ wasn’t just increasing NAD⁺ – the body was processing it
Researchers also measured 1-Methyl Nicotinamide (MNA), produced when NAD⁺ is metabolised.

MNA increased by 120% over the 30 days which suggests NAD⁺ pathways were actively processing within the body.

4. Significant improvements in mental wellbeing
Two validated clinical questionnaires showed statistically significant improvements in how participants felt.

The GHQ-12, a recognised measure of psychological wellbeing, improved by 10%, including:

  • +31% confidence
  • +23% improvement in low mood
  • +19% concentration


The Profile of Mood States (POMS) also improved significantly, including:

  • 32% less confusion
  • 17% greater vigour


Taken together, these results show measurable changes in key cellular energy markers alongside improvements in mental wellbeing after just 30 days of Thrive⁺.

3rd party quality control

Tested for optimal safety

Analysis
Specification
Result
Unit
Total Viable Count 
< 1,000
Conforms
CFU/g
Analysis Date: 28-Apr-2026
Enterobacteriaceae 
< 100
Conforms
CFU/g
Analysis Date: 28-Apr-2026
Yeasts 
< 100
Conforms
CFU/g
Analysis Date: 28-Apr-2026
Moulds 
< 100
Conforms
CFU/g
Analysis Date: 28-Apr-2026
E. Coli 
< 10
Conforms
CFU/g
Analysis Date: 28-Apr-2026
Salmonella 
Not detected in 25g
Conforms
g
Analysis Date: 28-Apr-2026
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What to expect

Thrive⁺ shows measurable cellular changes in 30 days, but it’s designed for long-term use to support cellular energy and vitality.

24 HOURS

Your cells begin producing more NAD⁺ from NR, supporting the cellular processes involved in energy production.

BY DAY 30

After 30 days of Thrive⁺, whole-blood NAD⁺ increased by 49% and CoQ10 by 57% in our pilot study.

BY DAY 45

Clinical research around this point suggests higher NAD⁺ availability may support changes in body composition, including lean muscle.

BY DAY 180

Sustained increases in NAD⁺ may support everyday energy and endurance. In one 2020 study, participants improved their 6-minute walking distance by 17.6 metres.

AFTER 365 DAYS

With continued use, the aim is to consistently support your NAD⁺ pathway and the cellular processes associated with long-term healthy ageing.

Interactions

If you take blood thinners or antiplatelet medication such as warfarin, clopidogrel or aspirin, speak to your doctor or pharmacist before using Thrive⁺, as trans-resveratrol and CoQ10 may affect bleeding or warfarin activity.

Caution is also sensible if you take blood-pressure medication, and high dose zinc supplements can reduce copper absorption.

If you’re pregnant, breastfeeding, taking prescription medication or have a medical condition, check with a healthcare professional before use.